Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 15/20 | 0.51 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885634 | 0.82 | KCNH2 (0.62) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2889546 | 0.81 | KCNH2 (0.57) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2882484 | 0.81 | KCNH2 (0.61) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2886862 | 0.79 | KCNH2 (0.58) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL8250765 | 0.78 | KCNH2 (0.56) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL14708784 | 0.78 | CACNA1I (0.59) | KCNH2CACNA1ICACNA1HCACNA1GKMT2A | |
| SCHEMBL14693997 | 0.78 | KCNH2 (0.50) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2886625 | 0.78 | KCNH2 (0.50) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2889559 | 0.78 | KCNH2 (0.83) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2887666 | 0.76 | KCNH2 (0.59) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | claimed |