Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 14/20 | 0.56 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886970 | 0.79 | KCNH2 (0.88) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL5067690 | 0.78 | KCNH2 (0.51) | KCNH2CACNA1ISCN5ACACNA1HCACNA1G | |
| SCHEMBL2888815 | 0.77 | KCNH2 (0.73) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL2881952 | 0.76 | KCNH2 (0.69) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL2889178 | 0.75 | KCNH2 (0.73) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL8250567 | 0.75 | KCNH2 (0.53) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL8243948 | 0.75 | KCNH2 (0.63) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL2885430 | 0.74 | KCNH2 (0.72) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL2889949 | 0.74 | KCNH2 (0.72) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 | |
| SCHEMBL2887799 | 0.74 | KCNH2 (0.79) | KCNH2CACNA1ISCN5ACACNA1HCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |