Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251587 | 1.00 | TSHR (0.39) | TSHRALDH1A1GABRR1LMNATHRB | |
| SCHEMBL1424261 | 0.97 | — | — | |
| SCHEMBL6697349 | 0.87 | GABRR1 (0.45) | TSHRALDH1A1GABRR1LMNATHRB | |
| SCHEMBL4705539 | 0.87 | GABRR1 (0.45) | TSHRALDH1A1GABRR1LMNATHRB | |
| SCHEMBL4202343 | 0.84 | ACE (0.38) | TSHRALDH1A1GABRR1LMNABLM | |
| SCHEMBL1640046 | 0.84 | — | — | |
| SCHEMBL9184383 | 0.83 | CAMK2A (0.43) | TSHRALDH1A1GABRR1LMNATHRB | |
| Hydrochloric Acid SCHEMBL2708490 | 0.81 | BLM (0.43) | TSHRALDH1A1GABRR1LMNATHRB | |
| SCHEMBL483277 | 0.80 | — | — | |
| SCHEMBL16029966 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080311083-A1 | Methods of Modulating Beta Cell Function | JOSLIN DIABETES CENTER, INC. (US) | 2008-12-18 | — | — | US | disclosed |
| US-7256176-B2 | Methods of modulating β cell function | JOSLIN DIABETES CENTER, INC. (US) | 2007-08-14 | — | — | US | disclosed |
| US-20060293246-A1 | Methods of modulating beta cell function | JOSLIN DIABETES CENTER, INC. | 2006-12-28 | — | — | US | disclosed |