Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | PRKDC | P78527 | 3/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | FGR | P09769 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086355 | 0.84 | SRC (0.66) | SRCPIK3CDPIK3CGPRKDCPIK3CA | |
| SCHEMBL2361494 | 0.81 | KDM4E (0.68) | SRCPIK3CDPIK3CGRETPRKDC | |
| SCHEMBL15779787 | 0.80 | RET (0.52) | SRCPIK3CDPIK3CGRETPRKDC | |
| SCHEMBL5066104 | 0.79 | SRC (0.61) | SRCPIK3CDPIK3CGRETPRKDC | |
| SCHEMBL3792927 | 0.77 | CYP1A2 (0.69) | SRCPIK3CDPIK3CGRETPRKDC | |
| SCHEMBL21308414 | 0.77 | SRC (0.59) | SRCPIK3CDPIK3CGRETPRKDC | |
| SCHEMBL14086588 | 0.76 | PIK3CD (0.62) | SRCPIK3CDPIK3CGPRKDCPIK3C2B | |
| SCHEMBL3611430 | 0.75 | SRC (0.72) | SRCPIK3CDPIK3CGRETPRKDC | |
| SCHEMBL21851263 | 0.74 | ADORA2A (0.51) | SRCRET | |
| SCHEMBL19623303 | 0.74 | ADORA2A (0.48) | SRCPIK3CDPIK3CGRETPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |