Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.61 |
| ▸ | ABL1 | P00519 | 4/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.55 |
| ▸ | PRKDC | P78527 | 7/20 | 0.55 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.53 |
| ▸ | YES1 | P07947 | 1/20 | 0.52 |
| ▸ | FGR | P09769 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | HCK | P08631 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086588 | 0.88 | PIK3CD (0.62) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL14086355 | 0.87 | SRC (0.66) | SRCABL1PIK3CDPRKDCPIK3CA | |
| SCHEMBL2361494 | 0.86 | KDM4E (0.68) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL129820 | 0.82 | PIK3CD (0.76) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL3792927 | 0.80 | CYP1A2 (0.69) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL21308414 | 0.80 | SRC (0.59) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL14086589 | 0.79 | PIK3CD (0.76) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL5067784 | 0.79 | SRC (0.50) | SRCPIK3CDPRKDCPIK3CAPIK3CB | |
| SCHEMBL15779787 | 0.78 | RET (0.52) | SRCABL1PIK3CDPRKDCKDR | |
| SCHEMBL26165823 | 0.78 | FGFR1 (0.74) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |