Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA4 | P54764 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | HEXA | P06865 | 1/20 | 0.36 |
| ▸ | HEXB | P07686 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2361495 | 0.80 | SMN1; SMN2 (0.40) | TLR8PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5066107 | 0.79 | TLR8 (0.40) | TLR8PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21048476 | 0.73 | PIK3CG (0.59) | EPHA4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8842104 | 0.71 | DCUN1D1 (0.53) | TLR8DCUN1D1TDP1TSHRKDM4E | |
| SCHEMBL13329283 | 0.70 | BTK (0.44) | EPHA4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13329241 | 0.68 | DPP4 (0.41) | EPHA4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13329735 | 0.66 | DPP4 (0.39) | EPHA4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13329315 | 0.66 | EPHA4 (0.62) | EPHA4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11496531 | 0.65 | GAA (0.38) | TLR8DCUN1D1HTR7TSHRKDM4E | |
| SCHEMBL13360836 | 0.65 | HEXA (0.40) | TLR8PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |