Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066107 | 0.85 | TLR8 (0.40) | SMN1; SMN2NPC1TP53TSHRRAB9A | |
| SCHEMBL5067787 | 0.80 | EPHA4 (0.41) | SMN1; SMN2NPC1TP53TSHRRAB9A | |
| SCHEMBL5748863 | 0.76 | MEN1 (0.42) | SMN1; SMN2ALDH1A1TP53RAB9AMEN1 | |
| SCHEMBL3782102 | 0.72 | PIK3CD (0.57) | SMN1; SMN2ALDH1A1TP53TSHRMEN1 | |
| SCHEMBL17505368 | 0.71 | BTK (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL28827843 | 0.68 | ADORA3 (0.45) | SMN1; SMN2ALDH1A1GAANPC1TSHR | |
| SCHEMBL12713498 | 0.66 | PIK3CD (0.50) | ALDH1A1TP53TSHRMEN1KMT2A | |
| SCHEMBL7540624 | 0.65 | XDH (0.42) | ALDH1A1ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL15020484 | 0.64 | DPP4 (0.43) | SMN1; SMN2ALDH1A1GAANPC1TP53 | |
| SCHEMBL2318766 | 0.64 | GPR84 (0.47) | ALDH1A1GAAADORA3HPGDADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358720-A2 | FUSED RING HETEROARYL KINASE INHIBITORS | The Regents of the University of California (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010045542-A2 | FUSED RING HETEROARYL KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-22 | — | — | WO | disclosed |