Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.68 |
| ▸ | HRH2 | P25021 | 2/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | HTR2C | P28335 | 2/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.68 |
| ▸ | HTR2B | P41595 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL30206347 | 1.00 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL15735971 | 0.88 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL25269204 | 0.84 | SLC6A2 (0.83) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL25268546 | 0.84 | SLC6A2 (0.83) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL25271341 | 0.83 | SLC6A4 (0.76) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL29096592 | 0.83 | LMNA (0.84) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL27912373 | 0.82 | SLC6A2 (0.93) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL4064 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL12543374 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNACHRM1 | |
| Diphenhydramine SCHEMBL1642652 | 0.82 | LMNA (0.61) | SLC6A2SLC6A4SLC6A3LMNACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 565 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1299680-C | Black-white formulation for treating insomnia | CHEN YANFANG (CN) | 2007-02-14 | — | — | CN | claimed |
| CN-1729970-A | Black-white formulation for treating insomnia | CHEN YANFANG (CN) | 2006-02-08 | — | — | CN | claimed |
| WO-2005094832-A1 | COMPOSITIONS COMPRISING MELOXICAM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-13 | — | — | WO | claimed |
| US-6348479-B1 | LIQUID OIL GEL, CASTOR OIL AND WATER IN OIL TYPE SURFACTANTS POLYGLYCERIN FATTY ACID ESTER | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | claimed |
| US-6159498-A | WATER-SOLUBLE DELIVERY DEVICE FOR APPLICATION TO MUCOSAL SURFACES | VIROTEX CORPORATION (US) | 2000-12-12 | — | — | US | claimed |
| EP-1029528-A1 | WATER-IN-OIL EMULSIFIER COMPOSITION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-23 | — | — | EP | claimed |
| JP-2017115-A | — | — | None | — | — | JP | disclosed |
| JP-4036243-A | — | — | None | — | — | JP | disclosed |
| JP-4327526-A | — | — | None | — | — | JP | disclosed |
| JP-4327528-A | — | — | None | — | — | JP | disclosed |
| EP-4746862-A2 | ENHANCED DELIVERY EPINEPHRINE AND PRODRUG COMPOSITIONS | Aquestive Therapeutics, Inc. (US) | 2026-05-27 | — | — | EP | disclosed |
| CN-122075448-A | Pharmaceutical composition with enhanced permeation | — | 2026-05-26 | — | — | CN | disclosed |
| CN-122055143-A | Solid compositions containing bromhexine | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | disclosed |
| EP-0387751-A2 | Medicated plasters | NITTO DENKO CORPORATION (JP) | 1990-09-19 | — | — | EP | disclosed |
| US-4900554-A | ACRYLIC ACID POLYMER AND CELLULOSE DERIVATIVE BLEND FOR ORAL CAVITY USE | TEIKOKU SEIYAKU CO., LTD. (JP) | 1990-02-13 | — | — | US | disclosed |
| EP-0351580-A2 | Sustained-release preparations and the process thereof | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1990-01-24 | — | — | EP | disclosed |
| JP-H0217115-A | SKIN-BEAUTIFYING COSMETIC | SHISEIDO CO LTD | 1990-01-22 | — | — | JP | disclosed |
| EP-0275550-A1 | Adhesive device for application to body tissue | TEIKOKU SEIYAKU KABUSHIKI KAISHA (JP) | 1988-07-27 | — | — | EP | disclosed |
| US-4670185-A | ANIONIC, CATIONIC, NONIONIC SURFACTANTS | LION CORPORATION (JP) | 1987-06-02 | — | — | US | disclosed |
| US-4590191-A | DIPHENHYDRAMINE OR SALT COMPONENT; ORAL OR RECTAL | MEDICHEMIE AG (CH) | 1986-05-20 | — | — | US | disclosed |