SCHEMBL5069151

SCHEMBL5069151

O=C(O)c1ccc(OCCc2c(CCNS(=O)(=O)CCN3CCCC3)n(C(c3ccccc3)c3ccccc3)c3cc(Cl)ccc23)cc1

nearest known ligand 0.89

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G4A P47712 20/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL82698 0.94 PLA2G4A (1.00) PLA2G4A
SCHEMBL1501153 0.94 PLA2G4A (1.00) PLA2G4A
SCHEMBL4780629 0.91 PLA2G4A (0.90) PLA2G4A
SCHEMBL4794971 0.89 PLA2G4A (0.90) PLA2G4A
SCHEMBL1500873 0.88 PLA2G4A (1.00) PLA2G4A
SCHEMBL1500805 0.88 PLA2G4A (1.00) PLA2G4A
SCHEMBL82817 0.88 PLA2G4A (1.00) PLA2G4A
SCHEMBL82965 0.88 PLA2G4A (1.00) PLA2G4A
SCHEMBL1501117 0.87 PLA2G4A (1.00) PLA2G4A
SCHEMBL1500994 0.87 PLA2G4A (1.00) PLA2G4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1892239-B1 Inhibitors of cytosolic phospholipase A2 WYETH LLC (US) 2013-02-20 EP disclosed
EP-1451154-B1 INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 WYETH CORP (US) 2008-01-16 EP disclosed