Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968590 | 0.82 | LTA4H (0.56) | ESR2KCNH2 | |
| SCHEMBL5069931 | 0.82 | LTA4H (0.56) | ESR2KCNH2 | |
| Hydrochloric Acid SCHEMBL3597194 | 0.81 | LTA4H (0.55) | ESR2KCNH2 | |
| Hydrochloric Acid SCHEMBL3598149 | 0.81 | LTA4H (0.55) | ESR2KCNH2 | |
| Hydrochloric Acid SCHEMBL3597192 | 0.81 | LTA4H (0.55) | ESR2KCNH2 | |
| SCHEMBL13436381 | 0.81 | LTA4H (0.61) | ESR2KCNH2 | |
| SCHEMBL3597992 | 0.80 | LTA4H (0.44) | ESR2 | |
| SCHEMBL3597998 | 0.80 | LTA4H (0.44) | ESR2 | |
| Hydrochloric Acid SCHEMBL3592985 | 0.80 | LTA4H (0.60) | ESR2KCNH2 | |
| Hydrochloric Acid SCHEMBL3592982 | 0.80 | LTA4H (0.60) | ESR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963276-A1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007073405-A1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-06-28 | — | — | WO | disclosed |