Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.59 |
| ▸ | APP | P05067 | 5/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.51 |
| ▸ | CTSD | P07339 | 2/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069588 | 1.00 | BACE1 (0.59) | BACE1APPBACE2CTSDMME | |
| SCHEMBL5073002 | 0.95 | BACE1 (0.58) | BACE1APPBACE2CTSDMME | |
| SCHEMBL5073999 | 0.94 | BACE1 (0.53) | BACE1APPBACE2CTSDMME | |
| SCHEMBL5141442 | 0.92 | BACE1 (0.56) | BACE1APPBACE2CTSD | |
| SCHEMBL5071381 | 0.92 | BACE1 (0.50) | BACE1APPBACE2CTSDMME | |
| SCHEMBL5070568 | 0.91 | BACE1 (0.52) | BACE1APPBACE2CTSD | |
| SCHEMBL5071430 | 0.88 | BACE1 (0.49) | BACE1APPBACE2CTSDMME | |
| SCHEMBL5074005 | 0.88 | BACE1 (0.46) | BACE1APPBACE2MMEMMEL1 | |
| SCHEMBL5070596 | 0.87 | BACE1 (0.57) | BACE1APPBACE2CTSDMME | |
| SCHEMBL5069576 | 0.86 | BACE1 (0.51) | BACE1APPBACE2MMEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |