Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.57 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069576 | 0.91 | BACE1 (0.51) | BACE1BACE2APPMMEMMEL1 | |
| SCHEMBL5069588 | 0.87 | BACE1 (0.59) | BACE1BACE2APPMMEMMEL1 | |
| SCHEMBL5069593 | 0.87 | BACE1 (0.59) | BACE1BACE2APPMMEMMEL1 | |
| SCHEMBL6294154 | 0.86 | BACE1 (0.66) | BACE1BACE2APPCTSD | |
| SCHEMBL5072992 | 0.85 | BACE1 (0.49) | BACE1BACE2APP | |
| SCHEMBL5071290 | 0.85 | BACE1 (0.49) | BACE1BACE2APPCTSD | |
| SCHEMBL5073002 | 0.84 | BACE1 (0.58) | BACE1BACE2APPMMEMMEL1 | |
| SCHEMBL5069587 | 0.84 | BACE1 (0.47) | BACE1BACE2APPCTSD | |
| SCHEMBL5071430 | 0.83 | BACE1 (0.49) | BACE1BACE2APPMMEMMEL1 | |
| SCHEMBL6295359 | 0.82 | BACE1 (0.59) | BACE1BACE2APPCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |