Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267956 | 0.79 | PDE4B (0.58) | PDE4BMTNR1BALDH1A1LMNAKMT2A | |
| SCHEMBL4948751 | 0.76 | PDE4B (0.70) | PDE4BMTNR1BP2RX7MAPT | |
| SCHEMBL1275581 | 0.70 | PDE4B (1.00) | PDE4B | |
| SCHEMBL1276433 | 0.69 | PDE4B (0.81) | PDE4B | |
| SCHEMBL1276130 | 0.68 | PDE4B (0.62) | PDE4BMTNR1BKCNH2ATM | |
| SCHEMBL4627075 | 0.68 | PDE4B (0.82) | PDE4B | |
| SCHEMBL2511729 | 0.67 | PDE4B (0.63) | PDE4BMTNR1B | |
| SCHEMBL4262700 | 0.67 | PDE4B (0.60) | PDE4BMTNR1BKCNH2 | |
| SCHEMBL12204105 | 0.66 | PDE4B (0.60) | PDE4BMTNR1B | |
| SCHEMBL4627565 | 0.65 | PDE4B (0.79) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944305-A1 | Quinoline derivatives as phosphodiesterase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-07-16 | — | — | EP | disclosed |