Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.49 |
| ▸ | CCR4 | P51679 | 4/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071978 | 0.94 | LMNA (0.46) | CACNA2D1CCR4SLC2A1KDM4EMAPT | |
| SCHEMBL1550558 | 0.86 | KDM4E (0.46) | CACNA2D1CCR4KDM4EMAPTNSD1 | |
| SCHEMBL1695719 | 0.85 | KDM4E (0.46) | CACNA2D1CCR4KDM4EMAPTNSD1 | |
| SCHEMBL5069903 | 0.85 | CHRM2 (0.60) | KDM4EMAPTNSD1HSD17B10 | |
| SCHEMBL5071096 | 0.81 | HRH3 (0.47) | CACNA2D1KDM4E | |
| SCHEMBL1695397 | 0.81 | TMEM97 (0.51) | CACNA2D1CCR4KDM4EMAPTNSD1 | |
| SCHEMBL5074614 | 0.80 | TMEM97 (0.50) | CCR4KDM4EMAPTNSD1HSD17B10 | |
| SCHEMBL5074652 | 0.80 | CHRM2 (0.65) | KDM4EMAPTNSD1HSD17B10 | |
| SCHEMBL1695371 | 0.76 | CACNA2D1 (0.51) | CACNA2D1KDM4EMAPTNSD1HSD17B10 | |
| SCHEMBL5073627 | 0.75 | HRH3 (0.44) | CACNA2D1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581167-A4 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON'S DISEASE AND TARDIVE DYSKINESIAS | ALPHA RES GROUP LLC (US) | 2008-10-29 | — | — | EP | claimed |
| JP-2006514917-A | — | — | 2006-05-18 | — | — | JP | claimed |
| EP-1581167-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON'S DISEASE AND TARDIVE DYSKINESIAS | Alpha Research Group, LLC (US) | 2005-10-05 | — | — | EP | claimed |
| WO-2004004660-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON’S DISEASE AND TARDIVE DYSKINESIAS | ALPHA RESEARCH GROUP, L.L.C. (US) | 2004-01-15 | — | — | WO | claimed |
| WO-2012163814-A1 | CANCER TREATMENT BY COMBINING DNA MOLECULES MIMICKING DOUBLE STRAND BREAKS WITH HYPERTHERMIA | INSTITUT CURIE (FR) | 2012-12-06 | — | — | WO | disclosed |