Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205051 | 0.92 | LSS (0.46) | LSSHPGDHTTCNR2LMNA | |
| SCHEMBL5092120 | 0.91 | LSS (0.46) | LSSHPGDHTTCNR2LMNA | |
| SCHEMBL7204735 | 0.90 | CA1 (0.43) | LSSHPGDHTTCNR2LMNA | |
| SCHEMBL4801885 | 0.85 | LSS (0.63) | LSSALDH1A1 | |
| SCHEMBL4801894 | 0.85 | LSS (0.63) | LSSALDH1A1 | |
| SCHEMBL4802106 | 0.83 | LSS (0.62) | LSSALDH1A1 | |
| SCHEMBL4802114 | 0.83 | LSS (0.62) | LSSALDH1A1 | |
| SCHEMBL7209261 | 0.83 | LSS (0.46) | LSSHPGDHTTCNR2LMNA | |
| SCHEMBL6528893 | 0.82 | CA1 (0.43) | HPGDHTTCNR2LMNAKMT2A | |
| SCHEMBL7203923 | 0.81 | CNR2 (0.47) | HPGDHTTCNR2LMNAGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-B1 | AMINOCYCLOHEXANE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-08-06 | — | — | EP | disclosed |