Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092120 | 0.88 | LSS (0.46) | LSSNPC1ALDH1A1CNR2L3MBTL1 | |
| SCHEMBL5067515 | 0.85 | LSS (0.54) | LSSALDH1A1USP2 | |
| SCHEMBL7205051 | 0.84 | LSS (0.46) | LSSALDH1A1CNR2LMNAHPGD | |
| SCHEMBL7204735 | 0.83 | CA1 (0.43) | LSSNPC1ALDH1A1CNR2LMNA | |
| SCHEMBL4798370 | 0.83 | LSS (0.51) | LSSALDH1A1HTTUSP2 | |
| SCHEMBL4798377 | 0.83 | LSS (0.51) | LSSALDH1A1HTTUSP2 | |
| SCHEMBL4803319 | 0.83 | LSS (0.63) | LSSALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL5070017 | 0.83 | LSS (0.45) | LSSNPC1ALDH1A1CNR2LMNA | |
| SCHEMBL4803325 | 0.83 | LSS (0.63) | LSSALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL7203923 | 0.81 | CNR2 (0.47) | NPC1ALDH1A1CNR2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |