Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | USP14 | P54578 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069179 | 0.87 | POLB (0.40) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL5070804 | 0.87 | POLB (0.40) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL5069177 | 0.87 | POLB (0.40) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL5069146 | 0.84 | POLB (0.44) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL5066621 | 0.84 | POLB (0.44) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL13051741 | 0.80 | HTT (0.46) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL5068723 | 0.80 | GAA (0.46) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL5066571 | 0.79 | KMT2A (0.64) | MAPTKDM4EHTTHPGDSMN1; SMN2 | |
| SCHEMBL13051739 | 0.79 | HTT (0.66) | POLBMAPTKDM4EGAAGFER | |
| SCHEMBL2285069 | 0.78 | ERN1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653947-B1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-01-16 | — | — | EP | claimed |