SCHEMBL5070927

SCHEMBL5070927

Cc1ccc(Sc2c(C(=O)NCC(=O)O)ncc3ccccc23)c(O)c1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 19/20 0.49
EGLN3 Q9H6Z9 3/20 0.49
VEGFA P15692 2/20 0.49
FLT1 P17948 2/20 0.49
FTO Q9C0B1 4/20 0.47
KDM6B O15054 1/20 0.45
KDM5B Q9UGL1 1/20 0.42
KDM2A Q9Y2K7 1/20 0.42
BBOX1 O75936 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9893450 0.84 EGLN1 (0.48) EGLN1EGLN3VEGFAFLT1FTO
SCHEMBL3916356 0.81 EGLN1 (0.53) EGLN1EGLN3VEGFAFLT1FTO
SCHEMBL31501044 0.74 EGLN1 (0.68) EGLN1EGLN3FTOKDM6BBBOX1
SCHEMBL821293 0.74 EGLN1 (0.68) EGLN1EGLN3FTOKDM6BBBOX1
SCHEMBL5073140 0.72 EGLN1 (0.65) EGLN1EGLN3FTOKDM6BKDM5B
SCHEMBL14310480 0.70 EGLN1 (0.71) EGLN1EGLN3VEGFAFLT1
SCHEMBL521828 0.70 EGLN1 (0.56) EGLN1EGLN3VEGFAFLT1FTO
SCHEMBL1921903 0.70 EGLN1 (0.67) EGLN1EGLN3VEGFAFLT1FTO
SCHEMBL522835 0.68 EGLN1 (0.66) EGLN1EGLN3FTOBBOX1
SCHEMBL3924202 0.68 EGLN1 (0.51) EGLN1EGLN3FTOKDM6BKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893186-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2008-03-05 EP disclosed
WO-2007146425-A2 COMPOUNDS AND METHODS FOR TREATMENT OF CHEMOTHERAPY-INDUCED ANEMIA FIBROGEN, INC. (US) 2007-12-21 WO disclosed
WO-2007047194-A2 METHODS FOR TREATING MITF-RELATED DISORDERS DANA-FARBER CANCER INSTITUTE, INC. (US) 2007-04-26 WO disclosed
WO-2006133391-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2006-12-14 WO disclosed
EP-1644336-A1 NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN FIBROGEN, INC. (US) 2006-04-12 EP disclosed
WO-2004108681-A1 NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN FIBROGEN, INC. (US) 2004-12-16 WO disclosed