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SCHEMBL5070976

SCHEMBL5070976

COc1ccc(S(=O)(=O)Nc2ccc3c(O)c(C(=O)NCC(=O)O)ncc3c2)cc1.O=C(O)CNC(=O)c1ncc2cc(NC(=O)Nc3ccccc3)ccc2c1O.O=C(O)CNC(=O)c1ncc2ccc(NC(=O)Nc3ccccc3)cc2c1O

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ EGLN2 Q96KS0 15/20 0.56
▸ EGLN1 Q9GZT9 15/20 0.56
▸ TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL523678 0.90 EGLN1 (0.58) EGLN2EGLN1
SCHEMBL522573 0.82 EGLN2 (0.80) EGLN2EGLN1
SCHEMBL523058 0.82 EGLN1 (0.67) EGLN2EGLN1
SCHEMBL523081 0.79 EGLN1 (0.77) EGLN2EGLN1
SCHEMBL4757894 0.77 EGLN1 (0.70) EGLN2EGLN1
SCHEMBL522413 0.77 EGLN1 (0.67) EGLN2EGLN1
SCHEMBL5072578 0.77 EGLN1 (0.67) EGLN2EGLN1
SCHEMBL27735259 0.76 PKM (0.48) EGLN2
SCHEMBL522111 0.74 EGLN1 (0.70) EGLN2EGLN1
SCHEMBL522758 0.74 EGLN1 (0.84) EGLN2EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893186-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2008-03-05 — — EP claimed
WO-2006133391-A2 IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT FIBROGEN, INC. (US) 2006-12-14 — — WO claimed