Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9355722 | 0.92 | TSHR (0.56) | TSHRTP53KDM4EALDH1A1PLA2G4B | |
| SCHEMBL3336310 | 0.92 | TSHR (0.56) | TSHRTP53KDM4EALDH1A1PLA2G4B | |
| SCHEMBL28897058 | 0.92 | TSHR (0.56) | TSHRTP53KDM4EALDH1A1PLA2G4B | |
| SCHEMBL11646248 | 0.92 | TSHR (0.56) | TSHRTP53KDM4EALDH1A1PLA2G4B | |
| SCHEMBL22719984 | 0.92 | TSHR (0.56) | TSHRTP53KDM4EALDH1A1PLA2G4B | |
| SCHEMBL17995727 | 0.92 | TSHR (0.56) | TSHRTP53KDM4EALDH1A1PLA2G4B | |
| SCHEMBL27968722 | 0.92 | KDM4E (0.49) | RARBTSHRTP53KDM4ENOD2 | |
| SCHEMBL1333648 | 0.92 | KDM4E (0.49) | RARBTSHRTP53KDM4ENOD2 | |
| SCHEMBL26622691 | 0.91 | TSHR (0.55) | RARBTSHRTP53KDM4EALDH1A1 | |
| SCHEMBL9356169 | 0.91 | TSHR (0.55) | RARBTSHRTP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | disclosed |