Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134459 | 0.76 | KCNH2 (0.47) | KCNH2DRD2HTR2ACACNA1ICCR1 | |
| SCHEMBL5069597 | 0.76 | KCNH2 (0.44) | KCNH2KMT2ALMNAOPRM1CACNA1I | |
| SCHEMBL2887276 | 0.75 | KCNH2 (0.62) | KCNH2MEN1KMT2ADRD2LMNA | |
| SCHEMBL2882393 | 0.74 | KCNH2 (0.60) | KCNH2DRD2LMNASLC6A4HRH1 | |
| SCHEMBL2889689 | 0.74 | KCNH2 (0.60) | KCNH2DRD2NPSR1DRD3OPRL1 | |
| SCHEMBL2884528 | 0.73 | KCNH2 (0.59) | KCNH2DRD2DRD3OPRL1OPRM1 | |
| SCHEMBL2881211 | 0.72 | KCNH2 (0.57) | KCNH2MEN1KMT2ADRD2LMNA | |
| SCHEMBL2881209 | 0.72 | KCNH2 (0.57) | KCNH2MEN1KMT2ADRD2LMNA | |
| SCHEMBL24485248 | 0.71 | MEN1 (0.52) | MEN1KMT2ANPSR1TACR1 | |
| SCHEMBL16546692 | 0.71 | POLB (0.39) | MEN1KMT2AOPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | claimed |