Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069597 | 0.76 | KCNH2 (0.44) | KCNH2ALDH1A1GAACACNA1I | |
| SCHEMBL5072469 | 0.76 | KCNH2 (0.51) | KCNH2HTR2ADRD2CACNA1ICCR1 | |
| SCHEMBL2882228 | 0.72 | KCNH2 (0.56) | KCNH2P2RX7DRD2CACNA1ICCR1 | |
| SCHEMBL2881476 | 0.72 | KCNH2 (0.55) | KCNH2ALDH1A1P2RX7DRD2CACNA1I | |
| SCHEMBL5071665 | 0.72 | KCNH2 (0.43) | KCNH2L3MBTL1CACNA1I | |
| SCHEMBL20868522 | 0.70 | ATM (0.56) | ATML3MBTL1ALDH1A1GAAP2RX7 | |
| SCHEMBL14419717 | 0.67 | SIGMAR1 (0.49) | HTR2AHTR2CDRD2 | |
| SCHEMBL2600032 | 0.66 | NR3C1 (0.42) | L3MBTL1ALDH1A1GAAP2RX7 | |
| SCHEMBL10202969 | 0.65 | KCNH2 (0.43) | KCNH2CACNA1I | |
| SCHEMBL14419800 | 0.65 | KCNH2 (0.39) | KCNH2DRD2CACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | claimed |
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |