SCHEMBL5072525

SCHEMBL5072525

O=C(NC1CN2CCC1CC2)Oc1ccc(-c2ccncc2)o1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
POLB P06746 1/20 0.48
HTR3A P46098 4/20 0.41
CHRNA7 P36544 6/20 0.41
HTR3E A5X5Y0 2/20 0.41
HTR3B O95264 2/20 0.41
HTR3D Q70Z44 2/20 0.41
HTR3C Q8WXA8 2/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA4 P43681 1/20 0.41
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
CHRM2 P08172 2/20 0.39
CHRM1 P11229 2/20 0.39
CHRM3 P20309 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5072920 1.00 ALDH1A1 (0.48) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5073098 0.89 CHRNA7 (0.51) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5072527 0.89 CHRNA7 (0.51) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL7005735 0.88 KCNH2 (0.49) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5070929 0.88 KCNH2 (0.49) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5076026 0.87 ALDH1A1 (0.50) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5073095 0.87 CHRNA7 (0.54) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5073041 0.87 CHRNA7 (0.54) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5070891 0.87 ALDH1A1 (0.50) ALDH1A1POLBHTR3ACHRNA7HTR3E
SCHEMBL5075254 0.85 CHRNA7 (0.48) ALDH1A1POLBHTR3ACHRNA7HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1545537-B9 ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION ASTRAZENECA AB (SE) 2008-08-20 EP claimed
EP-1545537-B1 ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION ASTRAZENECA AB (SE) 2007-04-04 EP claimed
EP-1259508-B1 NOVEL BIARYLCARBOXAMIDES ASTRAZENECA AB (SE) 2003-10-15 EP claimed