Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.48 |
| ▸ | HTR3A | P46098 | 6/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.48 |
| ▸ | HTR3B | O95264 | 5/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.48 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072520 | 1.00 | CHRNA7 (0.48) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5072904 | 0.89 | CHRNA7 (0.47) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5072545 | 0.89 | CHRNA7 (0.47) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5072518 | 0.87 | CHRNA7 (0.58) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5072529 | 0.87 | CHRNA7 (0.58) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5075187 | 0.85 | CHRNA7 (0.54) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5072538 | 0.85 | CHRNA7 (0.54) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4197179 | 0.84 | CHRNB2 (0.55) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5075127 | 0.84 | CHRNA7 (0.53) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7000386 | 0.84 | CHRNA7 (0.53) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B9 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | claimed |
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |
| EP-1259508-B1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2003-10-15 | — | — | EP | claimed |