Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 9/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3204702 | 1.00 | RORC (0.41) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3201340 | 0.93 | NPC1 (0.39) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3205108 | 0.93 | NPC1 (0.39) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3196777 | 0.93 | RORC (0.41) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3214887 | 0.92 | RORC (0.41) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3210356 | 0.90 | RORC (0.40) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3191043 | 0.90 | RORC (0.46) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3204623 | 0.90 | RORC (0.46) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3198602 | 0.87 | RORC (0.39) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3203598 | 0.87 | RORC (0.41) | RORCDHODHNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959960-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | claimed |
| WO-2007070683-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | claimed |