Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 15/20 | 0.47 |
| ▸ | HTR3A | P46098 | 5/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.43 |
| ▸ | HTR3B | O95264 | 4/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5076035 | 1.00 | CHRM2 (0.48) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL5072930 | 0.88 | CHRNA7 (0.52) | CHRNA7HTR3ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5073043 | 0.88 | CHRNA7 (0.48) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5070841 | 0.88 | MAPT (0.45) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL5135536 | 0.88 | CHRNA7 (0.52) | CHRNA7HTR3ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5072521 | 0.88 | CHRNA7 (0.48) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5072894 | 0.88 | MAPT (0.45) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL5070891 | 0.88 | ALDH1A1 (0.50) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL5076026 | 0.88 | ALDH1A1 (0.50) | CHRM2CHRM1CHRM3CHRNA7HTR3A | |
| SCHEMBL5072952 | 0.87 | CHRNA7 (0.44) | CHRM2CHRM1CHRM3CHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B9 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | claimed |
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |
| EP-1259508-B1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2003-10-15 | — | — | EP | claimed |