SCHEMBL5074249

SCHEMBL5074249

CC(C(=O)O)(c1ccccn1)c1ccccn1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
KDM4E B2RXH2 2/20 0.46
LMNA P02545 3/20 0.45
NAPRT Q6XQN6 1/20 0.45
P4HTM Q9NXG6 1/20 0.45
ALDH1A1 P00352 1/20 0.44
BLM P54132 2/20 0.43
CYP2D6 P10635 1/20 0.43
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
KMT2A Q03164 1/20 0.41
PTGS2 P35354 1/20 0.41
POLB P06746 1/20 0.41
CHRM2 P08172 1/20 0.41
SLC22A2 O15244 1/20 0.40
SLC22A1 O15245 1/20 0.40
PGR P06401 1/20 0.40
THRB P10828 1/20 0.40
ADRB3 P13945 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1131687 0.91 KDM4E (0.54) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL505194 0.84 L3MBTL1 (0.52) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL1827357 0.82 L3MBTL1 (0.55) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL8762152 0.82 L3MBTL1 (0.40) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL622397 0.81 L3MBTL1 (0.48) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL2086831 0.81 L3MBTL1 (0.48) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL1026708 0.81 L3MBTL1 (0.48) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL31073982 0.81 L3MBTL1 (0.48) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
SCHEMBL30818939 0.81 L3MBTL1 (0.48) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT
Hydrochloric Acid SCHEMBL17102116 0.81 L3MBTL1 (0.53) L3MBTL1SMN1; SMN2KDM4ELMNANAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931661-A1 ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2008-06-18 EP disclosed
WO-2007039389-A1 ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2007-04-12 WO disclosed
CN-1308324-C Quinazoline derivatives as alpha-1 adrenergic antagonists HOFFMANN LA ROCHE (CH) 2007-04-04 CN disclosed
CN-1545510-A Quinazoline derivatives as alpha-1 adrenergic antagonists - 2004-11-10 CN disclosed