Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.66 |
| ▸ | EGLN2 | Q96KS0 | 18/20 | 0.54 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523592 | 0.91 | EGLN1 (0.79) | EGLN1EGLN2THRATHRB | |
| SCHEMBL522669 | 0.91 | EGLN1 (0.66) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523424 | 0.89 | EGLN1 (0.78) | EGLN1EGLN2 | |
| SCHEMBL522013 | 0.89 | EGLN1 (0.66) | EGLN1EGLN2THRATHRB | |
| SCHEMBL4409409 | 0.86 | EGLN1 (0.77) | EGLN1EGLN2THRATHRB | |
| SCHEMBL4075054 | 0.85 | EGLN1 (0.71) | EGLN1EGLN2 | |
| SCHEMBL5072579 | 0.84 | EGLN1 (0.67) | EGLN1EGLN2THRATHRB | |
| SCHEMBL5072553 | 0.83 | EGLN1 (0.59) | EGLN1EGLN2THRATHRB | |
| SCHEMBL4757879 | 0.83 | EGLN1 (0.72) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523170 | 0.82 | EGLN1 (0.84) | EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | claimed |