Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GALR3 | O60755 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1330669 | 1.00 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Bromide SCHEMBL1330859 | 1.00 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Bromide SCHEMBL5077139 | 1.00 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Bromide SCHEMBL574667 | 1.00 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Bromide SCHEMBL707782 | 1.00 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Hydrochloric Acid SCHEMBL385262 | 0.96 | TBXAS1 (0.41) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Iodide SCHEMBL11782794 | 0.96 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Hydrochloric Acid SCHEMBL2952423 | 0.96 | TBXAS1 (0.41) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Iodide SCHEMBL580144 | 0.96 | PTGS1 (0.39) | PTGS1PTGS2MGLLFAAHNPC1 | |
| Hydrochloric Acid SCHEMBL1977590 | 0.96 | TBXAS1 (0.41) | PTGS1PTGS2MGLLFAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697465-B1 | POLYMER NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION | GEN ELECTRIC (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1697465-A2 | POLYMER NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061623-A2 | POLYMER NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050137310-A1 | Polymer nanocomposites and methods for their preparation | CITIBANK, N.A., AS COLLATERAL AGENT | 2005-06-23 | — | — | US | disclosed |