Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 8/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58549 | 0.89 | HRH3 (0.44) | ACVRL1MAP4K4MEN1KMT2A | |
| SCHEMBL5081034 | 0.86 | PDE1B (0.41) | ACVRL1RIPK1MAP4K4ALDH1A1KMT2A | |
| SCHEMBL57958 | 0.83 | MAP4K4 (0.46) | MAP4K4 | |
| SCHEMBL14312774 | 0.82 | PIK3CA (0.47) | ACVRL1PIK3CAMAP4K4KDM4E | |
| SCHEMBL16011367 | 0.80 | ACVRL1 (0.51) | ACVRL1MAP4K4KDM4EALDH1A1MEN1 | |
| SCHEMBL59827 | 0.79 | ACVRL1 (0.54) | ACVRL1PIK3CAKDM4EALDH1A1MEN1 | |
| SCHEMBL5076918 | 0.79 | ACVRL1 (0.54) | ACVRL1ALDH1A1MEN1KMT2A | |
| SCHEMBL14888176 | 0.78 | ACVRL1 (0.46) | ACVRL1KDM4EALDH1A1 | |
| SCHEMBL15019887 | 0.77 | FGFR1 (0.39) | ACVRL1MAP4K4 | |
| SCHEMBL15019263 | 0.77 | FGFR1 (0.36) | ACVRL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |