Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 12/20 | 0.47 |
| ▸ | MERTK | Q12866 | 9/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14888090 | 0.92 | ACVRL1 (0.47) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14313010 | 0.92 | ACVRL1 (0.46) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14313391 | 0.91 | MERTK (0.47) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14313282 | 0.89 | TYRO3 (0.52) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14327120 | 0.88 | TYRO3 (0.53) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL5076660 | 0.88 | ACVRL1 (0.59) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14313168 | 0.87 | KIT (0.42) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14312849 | 0.87 | TYRO3 (0.52) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14327127 | 0.86 | MERTK (0.49) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL14327106 | 0.86 | ACVRL1 (0.45) | TYRO3MERTKAXLACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |