Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.39 |
| ▸ | TUBB | P07437 | 6/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077800 | 0.87 | GRM5 (0.53) | GRM5TUBB4ATUBBTUBA3CTUBA1B | |
| Hydrochloric Acid SCHEMBL5082253 | 0.86 | GRM5 (0.52) | GRM5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13683878 | 0.76 | GRM5 (0.54) | GRM5MEN1KMT2ANPC1MAPT | |
| SCHEMBL13683865 | 0.72 | GRM5 (0.59) | GRM5MEN1KMT2ANPC1MAPT | |
| SCHEMBL5504295 | 0.70 | ABL1 (0.39) | SMPD3PDPK1MEN1KMT2AMAPT | |
| SCHEMBL5100415 | 0.69 | GRM5 (0.63) | GRM5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8338124 | 0.69 | HTT (0.48) | GRM5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL660519 | 0.68 | MAPT (0.55) | NPC1MAPTNFKB1RAB9ANFKB2 | |
| Hydrochloric Acid SCHEMBL5315800 | 0.68 | HTT (0.47) | GRM5TUBB4ATUBBTUBA3CTUBA1B | |
| Hydrochloric Acid SCHEMBL5101454 | 0.68 | GRM5 (0.62) | GRM5TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393959-B2 | Di-aryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK & CO. INC. (US) | 2008-07-01 | — | — | US | claimed |
| EP-1613265-A4 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2007-02-14 | — | — | EP | claimed |
| US-20060193926-A1 | Di-arylsubstituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2006-08-31 | — | — | US | claimed |
| EP-1613265-A2 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004089308-A2 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2004-10-21 | — | — | WO | claimed |
| US-7393959-B2 | Di-aryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK & CO. INC. (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1613265-A4 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2007-02-14 | — | — | EP | disclosed |
| US-20060193926-A1 | Di-arylsubstituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2006-08-31 | — | — | US | disclosed |
| EP-1613265-A2 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004089308-A2 | DI-ARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060193926-A1 | Di-arylsubstituted pyrrole modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRIN2B | GRM5 1/4885SMPD3 4708/4885TUBB4A 3866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.