Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 4/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5315800 | 0.99 | HTT (0.47) | HTTGRM5ATMTUBB4ATUBB | |
| SCHEMBL13683864 | 0.82 | GRM5 (0.69) | GRM5 | |
| SCHEMBL5262454 | 0.81 | TUBB4A (0.40) | GRM5ATMTUBB4ATUBBTUBA3C | |
| SCHEMBL13683899 | 0.77 | GRM5 (0.59) | GRM5 | |
| SCHEMBL13683888 | 0.76 | GRM5 (0.67) | GRM5 | |
| SCHEMBL31689354 | 0.76 | SMN1; SMN2 (0.50) | HTTATMMEN1KMT2APDE10A | |
| SCHEMBL5077800 | 0.75 | GRM5 (0.53) | GRM5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13683936 | 0.75 | GRM5 (0.76) | GRM5 | |
| SCHEMBL13683878 | 0.75 | GRM5 (0.54) | GRM5MEN1KMT2A | |
| SCHEMBL5379182 | 0.75 | SYK (0.56) | HTTATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024074-A2 | FUSED HETEROBICYCLO SUBSTITUTED PHENYL METABOTROPIC GLUTAMATE-5 MODULATORS | MERCK & CO., INC. (US) | 2004-03-25 | — | — | WO | disclosed |