Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | INSRR | P14616 | 1/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070971 | 0.83 | IGF1R (0.45) | IGF1RCYP3A4KDRMAPK1INSR | |
| SCHEMBL4070968 | 0.83 | IGF1R (0.45) | IGF1RCYP3A4KDRMAPK1INSR | |
| SCHEMBL5083358 | 0.81 | IGF1R (0.58) | IGF1RCYP3A4KDRMAPK1INSR | |
| SCHEMBL5258044 | 0.80 | IGF1R (0.58) | IGF1RCYP3A4KDRMAPK1INSR | |
| SCHEMBL1566539 | 0.80 | IGF1R (0.44) | IGF1RCYP3A4KDRMAPK1INSR | |
| SCHEMBL5076858 | 0.80 | IGF1R (0.58) | IGF1RCYP3A4MAPK1INSRMAPK3 | |
| SCHEMBL5076854 | 0.80 | IGF1R (0.58) | IGF1RCYP3A4MAPK1INSRMAPK3 | |
| SCHEMBL5082928 | 0.79 | IGF1R (0.40) | IGF1RCYP3A4KDRMAPK1YES1 | |
| SCHEMBL1565302 | 0.79 | IGF1R (0.42) | IGF1RCYP3A4KDRMAPK1INSR | |
| SCHEMBL5083550 | 0.78 | IGF1R (0.40) | IGF1RCYP3A4FGFR1FLT3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | claimed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |