Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080265 | 0.88 | RAB9A (0.35) | IGF1RCYP3A4KDM4EALDH1A1NPC1 | |
| SCHEMBL5084929 | 0.86 | IGF1R (0.47) | IGF1RCYP3A4KDM4EALDH1A1NPC1 | |
| SCHEMBL5083767 | 0.85 | IGF1R (0.46) | IGF1RCYP3A4KDM4EALDH1A1NPC1 | |
| SCHEMBL5078897 | 0.78 | TNK2 (0.40) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5079147 | 0.78 | IGF1R (0.48) | IGF1RCYP3A4TNK2FGFR1FLT3 | |
| SCHEMBL5082157 | 0.77 | IGF1R (0.38) | IGF1RCYP3A4NPC1RAB9ATNK2 | |
| SCHEMBL4070971 | 0.76 | IGF1R (0.45) | IGF1RCYP3A4TNK2FGFR1FLT3 | |
| SCHEMBL4070968 | 0.76 | IGF1R (0.45) | IGF1RCYP3A4TNK2FGFR1FLT3 | |
| SCHEMBL5082928 | 0.75 | IGF1R (0.40) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5078929 | 0.75 | IGF1R (0.35) | IGF1RCYP3A4KCNH2HRH3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |