Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 6/20 | 0.43 |
| ▸ | UMPS | P11172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361970 | 1.00 | KDM4E (0.46) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL2524005 | 0.95 | KDM4E (0.46) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL375988 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL7948406 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL2185989 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL313768 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8789697 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL10661597 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL1682962 | 0.77 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL6266811 | 0.76 | PNP (0.47) | KDM4EGMNNLMNAMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545545-A4 | COMPOUNDS WITH THE BICYCLO 4.2.1 NONANE SYSTEM FOR THE TREATMENT OF i FLAVIVIRIDAE /i INFECTIONS | PHARMASSET INC (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1545545-A2 | COMPOUNDS WITH THE BICYCLO 4.2.1 NONANE SYSTEM FOR THE TREATMENT OF i FLAVIVIRIDAE /i INFECTIONS | Pharmasset, Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004013300-A2 | COMPOUNDS WITH THE BICYCLO[4.2.1]NONANE SYSTEM FOR THE TREATMENT OF FLAVIVIRIDAE INFECTIONS | PHARMASSET INC. (US) | 2004-02-12 | — | — | WO | disclosed |