Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.59 |
| ▸ | PI4KA | P42356 | 1/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.59 |
| ▸ | AHCY | P23526 | 4/20 | 0.53 |
| ▸ | ADA | P00813 | 4/20 | 0.52 |
| ▸ | PDE2A | O00408 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9615986 | 0.94 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL6693196 | 0.93 | ADORA2A (0.52) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL8585725 | 0.92 | ADA (0.55) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL29782939 | 0.91 | ADA (0.60) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL29782924 | 0.88 | ADA (0.67) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL29782849 | 0.88 | ADA (0.67) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL8585202 | 0.88 | ADA (0.58) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL8352543 | 0.87 | ADORA2A (0.63) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL6688401 | 0.84 | ADORA2A (0.49) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL5082995 | 0.83 | ADORA2A (0.46) | ADORA2AADORA1ADORA2BPI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004106350-A1 | NUCLEOSIDE ANALOGS AS VIRAL POLYMERASE INHIBITORS | BIOCRYST PHARMACEUTICAL, INC. (US) | 2004-12-09 | — | — | WO | claimed |
| US-20040014722-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | claimed |
| US-7388002-B2 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
| WO-2004106350-A1 | NUCLEOSIDE ANALOGS AS VIRAL POLYMERASE INHIBITORS | BIOCRYST PHARMACEUTICAL, INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| US-20040014722-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014722-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | NSUN2, POLR2H, NSUN3 | ADORA2A 2690/4885ADORA1 1890/4885ADORA2B 1705/4885 |
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | POLR2H, NSUN2, POLR2E | ADORA2A 1427/4885ADORA1 1330/4885ADORA2B 1062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.