Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | JAK1 | P23458 | 9/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054080 | 0.73 | MAPK14 (0.58) | MAPK14 | |
| SCHEMBL7233424 | 0.69 | KDM4E (0.64) | POLB | |
| SCHEMBL19674424 | 0.66 | MAOA (0.46) | JAK2JAK1 | |
| SCHEMBL787539 | 0.65 | CRBN (0.58) | POLBPARP1HTTESR2 | |
| SCHEMBL31409597 | 0.65 | CRBN (0.58) | JAK2JAK1POLBPARP1HTT | |
| SCHEMBL5946827 | 0.64 | CRBN (0.56) | JAK2JAK1POLBPARP1HTT | |
| SCHEMBL12874117 | 0.64 | CRBN (0.52) | BRD4PLK1JAK2JAK1 | |
| SCHEMBL27624826 | 0.63 | MAPT (0.58) | POLB | |
| SCHEMBL787143 | 0.62 | MAOA (0.42) | POLBPARP1HTTESR2 | |
| SCHEMBL19903421 | 0.62 | JAK2 (0.67) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907358-A2 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | Palau Pharma, S.A. (ES) | 2008-04-09 | — | — | EP | claimed |
| WO-2007000340-A2 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | claimed |