Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flumethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.82 |
| ▸ | PGR | P06401 | 4/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.82 |
| ▸ | AR | P10275 | 3/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | RAB9A | P51151 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | APEX1 | P27695 | 1/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.82 |
| ▸ | IKBKB | O14920 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone SCHEMBL516602 | 0.93 | HIF1A (0.95) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Dexamethasone SCHEMBL1376472 | 0.93 | HIF1A (0.95) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Dexamethasone SCHEMBL2637829 | 0.93 | HIF1A (0.95) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Flumethasone SCHEMBL5381025 | 0.91 | CYP3A4 (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Betamethasone SCHEMBL21790369 | 0.91 | HIF1A (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Betamethasone SCHEMBL24556970 | 0.91 | HIF1A (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Betamethasone SCHEMBL20816248 | 0.91 | HIF1A (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Betamethasone SCHEMBL21261932 | 0.91 | HIF1A (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Betamethasone SCHEMBL13046610 | 0.91 | HIF1A (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 | |
| Betamethasone SCHEMBL13026138 | 0.91 | HIF1A (1.00) | HIF1ANR3C1CYP3A4PGRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011646-B1 | PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR THEIR ADMINISTRATION | LINK PRODUCTS LTD (GB) | 2005-08-17 | — | — | EP | claimed |
| US-6413496-B1 | CONTAINER OF DRUG AND SOLVENT; VALVE FOR DELIVERING AEROSOL | BIOGLAND IRELAND (R&D) LIMITED (IE) | 2002-07-02 | — | — | US | claimed |
| EP-1011646-A1 | PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR THEIR ADMINISTRATION | BIOGLAN IRELAND (R & D) LIMITED (IE) | 2000-06-28 | — | — | EP | claimed |
| WO-1998024420-A1 | PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR THEIR ADMINISTRATION | BIOGLAN IRELAND (R & D) LIMITED (IE) | 1998-06-11 | — | — | WO | claimed |
| US-7384519-B2 | Process for the purification of pharmaceutical grade HFC-134a and polymer grade HCFC-22 | HONEYWELL INTERNATIONAL INC. (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1011646-B1 | PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR THEIR ADMINISTRATION | LINK PRODUCTS LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| WO-2005063660-A2 | METHOD FOR THE PURIFICATION OF PHARMACEUTICAL GRADE HFC-134A AND POLYMER GRADE HCFC-22 | HONEYWELL INTERNATIONAL INC. (US) | 2005-07-14 | — | — | WO | disclosed |
| US-20050133360-A1 | Process for the purification of pharmaceutical grade HFC-134a and polymer grade HCFC-22 | HONEYWELL INTERNATIONAL INC. | 2005-06-23 | — | — | US | disclosed |
| US-6413496-B1 | CONTAINER OF DRUG AND SOLVENT; VALVE FOR DELIVERING AEROSOL | BIOGLAND IRELAND (R&D) LIMITED (IE) | 2002-07-02 | — | — | US | disclosed |
| EP-1011646-A1 | PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR THEIR ADMINISTRATION | BIOGLAN IRELAND (R & D) LIMITED (IE) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998024420-A1 | PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR THEIR ADMINISTRATION | BIOGLAN IRELAND (R & D) LIMITED (IE) | 1998-06-11 | — | — | WO | disclosed |