Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 6/20 | 1.00 |
| ▸ | AR | P10275 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.75 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flumethasone SCHEMBL10422222 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL4046 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL9910827 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL20169795 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL3167856 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL4555 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL19327158 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL11853190 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL2855052 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT | |
| Flumethasone SCHEMBL3167846 | 1.00 | CYP3A4 (1.00) | CYP3A4PGRARHIF1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021360-A1 | Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase | EPIGENESIS PHARMACEUTICALS, LLC | 2007-01-25 | — | — | US | claimed |
| EP-1205218-B1 | Topical antipsoriaticum comprising urea, a corticoid and a desinfectant | BENKERT EUGEN GEORG DR MED DEN (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1205218-A1 | Topical antipsoriaticum comprising urea, a corticoid and a desinfectant | Benkert, Eugen Georg, Dr.med.dent. (DE) | 2002-05-15 | — | — | EP | claimed |
| US-7214807-B2 | Method for the preparation of fluticasone and related 17β-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods | ABBOTT LABORATORIES (US) | 2007-05-08 | — | — | US | disclosed |
| US-20070021360-A1 | Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase | EPIGENESIS PHARMACEUTICALS, LLC | 2007-01-25 | — | — | US | disclosed |
| US-20050090675-A1 | Process for preparing highly pure androstane 17-beta-carboxylic acids and 17-beta-carbothioic acid fluoromethyl esters thereof | S.N.I.F.F. ITALIA S.P.A. (IT) | 2005-04-28 | — | — | US | disclosed |
| US-20040209854-A1 | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods | ABBVIE INC. | 2004-10-21 | — | — | US | disclosed |
| EP-1257531-B1 | METHOD FOR THE PREPARATION OF CARBOTHIOIC ACIDS | ABBOTT LAB (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1205218-B1 | Topical antipsoriaticum comprising urea, a corticoid and a desinfectant | BENKERT EUGEN GEORG DR MED DEN (DE) | 2004-03-31 | — | — | EP | disclosed |
| US-20020133032-A1 | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods | ABBOTT LABORATORIES | 2002-09-19 | — | — | US | disclosed |
| EP-1205218-A1 | Topical antipsoriaticum comprising urea, a corticoid and a desinfectant | Benkert, Eugen Georg, Dr.med.dent. (DE) | 2002-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090675-A1 | Process for preparing highly pure androstane 17-beta-carboxylic acids and 17-beta-carbothioic acid fluoromethyl esters thereof | CYP17A1, HSD17B11, HSD17B7 | CYP3A4 259/4885PGR 593/4885AR 142/4885 |
| US-20020133032-A1 | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods | HSD17B7, CYP17A1, NR5A1 | CYP3A4 148/4885PGR 1622/4885AR 498/4885 |
| US-20040209854-A1 | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods | HSD17B7, CYP17A1, NR5A1 | CYP3A4 148/4885PGR 1622/4885AR 498/4885 |
| US-20070021360-A1 | Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase | RECQL, GSS, DDX17 | CYP3A4 2529/4885PGR 965/4885AR 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.