Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.53 |
| ▸ | CACNA2D1 | P54289 | 8/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 8/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864403 | 0.85 | POLB (0.49) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL8446326 | 0.85 | CACNA2D1 (0.44) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL3861150 | 0.81 | ALOX5 (0.47) | ALOX5CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL3890903 | 0.78 | CACNA2D1 (0.64) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL3866660 | 0.76 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5026257 | 0.76 | KCNA5 (0.59) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL5080780 | 0.76 | CACNA2D1 (0.49) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL3869733 | 0.76 | DRD3 (0.62) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL3864509 | 0.76 | DRD3 (0.68) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL3871235 | 0.73 | CACNA2D1 (0.60) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186726-B2 | Preferentially substituted calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-03-06 | — | — | US | claimed |
| US-20040147529-A1 | Preferentially substituted calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2004-07-29 | — | — | US | claimed |
| US-20080300262-A1 | Combination Therapy for Relief of Pain | ZALICUS PHARMACEUTICALS LTD. (CA) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147529-A1 | Preferentially substituted calcium channel blockers | CACNA1B, CACNA1C, CACNA1D | ALOX5 1123/4885CACNA2D1 36/4885CACNA1B 1/4885 |
| US-20080300262-A1 | Combination Therapy for Relief of Pain | CACNA1B, TRPV1, ORAI1 | ALOX5 770/4885CACNA2D1 90/4885CACNA1B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.