Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5445187 | 0.82 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3NOS2CYP2D6 | |
| SCHEMBL21381556 | 0.77 | SLC6A2 (0.43) | SLC6A2SLC6A4CACNA2D1HTR1AHTR1D | |
| SCHEMBL21381558 | 0.76 | SLC6A2 (0.47) | SLC6A2SLC6A4CACNA2D1HTR1AHTR1D | |
| Succinic Acid SCHEMBL4387 | 0.75 | SLC6A2 (0.60) | SLC6A2SLC6A4CACNA2D1SLC6A3CYP2D6 | |
| SCHEMBL29974877 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4CACNA2D1SLC6A3HTR1A | |
| SCHEMBL21742740 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4CACNA2D1SLC6A3HTR1A | |
| SCHEMBL28559855 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4CACNA2D1SLC6A3HTR1A | |
| SCHEMBL4388 | 0.70 | SLC6A2 (0.41) | SLC6A2SLC6A4CACNA2D1HTR1AHTR1D | |
| Phenyl Propionic Acid SCHEMBL11232741 | 0.69 | KEAP1 (0.45) | SLC6A2SLC6A4SLC6A3NOS2CYP2D6 | |
| SCHEMBL5137521 | 0.69 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3HTR1ANOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008133884-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-11-06 | — | — | WO | disclosed |