Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 7/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28283004 | 0.85 | MAPK8 (0.57) | SYKAURKBCSF1RSIRT2AURKA | |
| SCHEMBL5078980 | 0.83 | PDE4B (0.64) | PTGS1PTGS2SYKAKR1C3AKR1C2 | |
| SCHEMBL5078983 | 0.83 | SIRT3 (0.54) | PTGS1PTGS2SYKAKR1C3AKR1C2 | |
| SCHEMBL479807 | 0.83 | SIRT2 (0.54) | PTGS1PTGS2KDM4ESIRT3TDP1 | |
| SCHEMBL28284462 | 0.82 | SIRT2 (0.54) | AKR1C3AKR1C2SIRT3TDP1SIRT2 | |
| SCHEMBL28283015 | 0.82 | SIRT1 (0.56) | PTGS1PTGS2SYKAURKBSIRT2 | |
| SCHEMBL2714846 | 0.81 | SIRT2 (0.53) | KDM4EHIF1AKMT2APKMSIRT3 | |
| SCHEMBL11019931 | 0.81 | PTGS1 (0.65) | PTGS1PTGS2KDM4ECYP3A4CYP2C9 | |
| SCHEMBL9409184 | 0.81 | SYK (0.57) | SYKAKR1C3AKR1C2KMT2AAURKB | |
| SCHEMBL28283001 | 0.81 | CCNA2 (0.50) | SYKKMT2ASIRT2SIRT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132505-A1 | Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132505-A1 | Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine | CNR2, CNR1, PDE4A | PTGS1 336/4885PTGS2 380/4885KDM4E 1501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.