Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944783 | 0.83 | GRM2 (0.44) | GRM2HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL16682332 | 0.74 | HDAC3 (0.51) | HDAC1HDAC3HDAC2NCOR2GPR119 | |
| SCHEMBL2227505 | 0.73 | HTR2C (0.41) | HDAC1HDAC3HDAC2NCOR2EPHX2 | |
| SCHEMBL6223825 | 0.72 | GRM2 (0.38) | GRM2HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL7640149 | 0.72 | LMNA (0.38) | HDAC1HDAC3HDAC2NCOR2EPHX2 | |
| SCHEMBL28614083 | 0.72 | HDAC3 (0.37) | GRM2HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL18067962 | 0.72 | HDAC3 (0.46) | HDAC1HDAC3HDAC2NCOR2EPHX2 | |
| SCHEMBL8487620 | 0.72 | AKT1 (0.38) | GRM2HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL30400038 | 0.71 | CYP17A1 (0.46) | GRM2HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL3156567 | 0.71 | HDAC1 (0.48) | HDAC1HDAC3HDAC2NCOR2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132505-A1 | Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132505-A1 | Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine | CNR2, CNR1, PDE4A | GRM2 273/4885HDAC1 920/4885HDAC3 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.