Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.59 |
| ▸ | INSR | P06213 | 5/20 | 0.59 |
| ▸ | LCK | P06239 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.59 |
| ▸ | RET | P07949 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.59 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.59 |
| ▸ | EPHA4 | P54764 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401707 | 0.88 | IGF1R (0.62) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400527 | 0.83 | IGF1R (0.69) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400528 | 0.83 | IGF1R (0.69) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400545 | 0.83 | IGF1R (0.69) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL402366 | 0.82 | IGF1R (0.58) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400503 | 0.81 | IGF1R (0.57) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400064 | 0.80 | IGF1R (0.68) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL399486 | 0.80 | IGF1R (0.54) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400056 | 0.79 | IGF1R (0.63) | IGF1RINSRLCKKDRKIT | |
| SCHEMBL400273 | 0.79 | IGF1R (0.55) | IGF1RINSRLCKKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | IGF1R, IGFBP6, CDK6 | IGF1R 1/4885INSR 104/4885LCK 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.