Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508578 | 0.83 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2D6PIK3R1 | |
| SCHEMBL5225752 | 0.83 | KCNH2 (0.51) | KCNH2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL5227177 | 0.81 | KCNH2 (0.48) | KCNH2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL5228111 | 0.80 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2D6PIK3R1 | |
| SCHEMBL508181 | 0.79 | KCNH2 (0.47) | KCNH2CYP3A4PIK3R1PIK3CALMNA | |
| SCHEMBL5228148 | 0.79 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2D6PIK3R1 | |
| SCHEMBL5229314 | 0.78 | KCNH2 (0.50) | KCNH2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL5261967 | 0.78 | KCNH2 (0.50) | KCNH2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL5225076 | 0.77 | KCNH2 (0.51) | KCNH2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL5226919 | 0.77 | KCNH2 (0.51) | KCNH2CYP3A4CYP2C9CYP2D6PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029192-A1 | Pyrazole Derivatives | PFIZER INC | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029192-A1 | Pyrazole Derivatives | POLRMT, PDCD11, DPYD | KCNH2 3548/4885CYP3A4 62/4885CYP2C9 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.