Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Neboglamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 3/20 | 0.53 |
| ▸ | GRIN2B known ✓ | Q13224 | 3/20 | 0.53 |
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.41 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neboglamine SCHEMBL1353060 | 1.00 | LMNA (1.00) | LMNABLMGRIN1GRIN2BEPHX2 | |
| SCHEMBL3926158 | 0.73 | LMNA (0.57) | LMNABLMEPHX2CCKBR | |
| SCHEMBL3926164 | 0.73 | LMNA (0.57) | LMNABLMEPHX2CCKBR | |
| SCHEMBL10132091 | 0.73 | LMNA (0.56) | LMNABLMEPHX2DPP4DPP8 | |
| SCHEMBL30799584 | 0.73 | BLM (0.56) | LMNABLMGRIN1GRIN2BEPHX2 | |
| SCHEMBL3964164 | 0.72 | LMNA (0.55) | LMNABLMEPHX2 | |
| Hydrochloric Acid SCHEMBL29904534 | 0.71 | LMNA (0.54) | LMNABLMEPHX2 | |
| SCHEMBL14285665 | 0.70 | LMNA (0.54) | LMNABLMGRIN1GRIN2BDPP4 | |
| SCHEMBL14285569 | 0.70 | LMNA (0.54) | LMNABLMGRIN1GRIN2BDPP4 | |
| SCHEMBL3345888 | 0.69 | EPHX2 (0.53) | LMNABLMGRIN1GRIN2BEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1903028-A1 | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects | Tschollar,, Werner (CH) | 2008-03-26 | — | — | EP | disclosed |