Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.44 |
| ▸ | INSR | P06213 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139324 | 0.87 | ALDH1A1 (0.38) | IGF1RINSRALDH1A1CYP1A2HPGD | |
| SCHEMBL399522 | 0.85 | PIK3CD (0.50) | IGF1RINSRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL5139584 | 0.83 | IGF1R (0.40) | IGF1RINSREGFR | |
| SCHEMBL5137414 | 0.81 | IGF1R (0.41) | IGF1RINSRALDH1A1CYP1A2HPGD | |
| SCHEMBL5086449 | 0.81 | CYP1A2 (0.36) | IGF1RALDH1A1CYP1A2HPGDALOX15 | |
| SCHEMBL399311 | 0.76 | KDR (0.49) | IGF1RPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5258556 | 0.73 | SRC (0.43) | IGF1RINSRALDH1A1CYP1A2HPGD | |
| SCHEMBL399505 | 0.73 | EGFR (0.47) | IGF1RPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL401210 | 0.72 | IGF1R (0.58) | IGF1RINSRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL399698 | 0.72 | BTK (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |