Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | YES1 | P07947 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5081269 | 0.92 | CYP3A4 (0.39) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5258044 | 0.90 | IGF1R (0.58) | IGF1RCYP3A4TNK2KDREGFR | |
| SCHEMBL5082157 | 0.88 | IGF1R (0.38) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5082928 | 0.88 | IGF1R (0.40) | IGF1RCYP3A4TNK2KDRYES1 | |
| SCHEMBL5085497 | 0.87 | TNK2 (0.44) | IGF1RCYP3A4TNK2EGFR | |
| SCHEMBL5081943 | 0.84 | IGF1R (0.35) | IGF1RCYP3A4YES1 | |
| SCHEMBL5083767 | 0.79 | IGF1R (0.46) | IGF1RCYP3A4TNK2KDREGFR | |
| SCHEMBL5086159 | 0.79 | TNK2 (0.35) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5083358 | 0.76 | IGF1R (0.58) | IGF1RCYP3A4TNK2KDREGFR | |
| SCHEMBL5086596 | 0.75 | TNK2 (0.42) | IGF1RCYP3A4TNK2KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |