Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082157 | 0.90 | IGF1R (0.38) | IGF1RCYP3A4TNK2NPC1RAB9A | |
| SCHEMBL5085063 | 0.90 | IGF1R (0.42) | IGF1RCYP3A4TNK2EGFRINSR | |
| SCHEMBL5258044 | 0.87 | IGF1R (0.58) | IGF1RCYP3A4TNK2EGFRINSR | |
| SCHEMBL5084929 | 0.87 | IGF1R (0.47) | IGF1RCYP3A4TNK2EGFRINSR | |
| SCHEMBL5083550 | 0.85 | IGF1R (0.40) | IGF1RCYP3A4TNK2NPC1RAB9A | |
| SCHEMBL5083969 | 0.79 | IGF1R (0.46) | IGF1RCYP3A4TNK2EGFRINSR | |
| SCHEMBL5081269 | 0.79 | CYP3A4 (0.39) | IGF1RCYP3A4TNK2KDM4EALDH1A1 | |
| SCHEMBL5080265 | 0.78 | RAB9A (0.35) | IGF1RCYP3A4TNK2NPC1RAB9A | |
| SCHEMBL5138226 | 0.78 | IGF1R (0.56) | IGF1RCYP3A4TNK2EGFRINSR | |
| SCHEMBL5085066 | 0.76 | IGF1R (0.44) | IGF1RCYP3A4TNK2EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |